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1. Remove the pen cap, by pulling the cap off.

2. Unscrew the cartridge holder (the body of the pen) from the main pen body.

3. Ensure the piston rod is fully pushed in.

4. Insert the new cartridge into the holder, often with the metal-capped (threaded) end first.

5. Screw the cartridge holder back onto the main pen body until it is secure.

Here is a video on how to insert a new cartridge:

This video shows once your cartridge is loaded in how to prime it.

Once it is primed properly, if you do not remove the cartridge from the pen, it will be ready to use again without needing to be primed. If you are switching out cartridges in one pen, this will need to be done before each use.

Use the dose selector dial on the pen to select your desired dose. You can simply turn the dial backwards (counter-clockwise) to reduce the dose if you accidentally dial too high. You cannot, however, turn the dial back once the dose has been fully injected.

After pushing the injection button all the way in until the dose counter shows '0', you must keep the needle in your skin and hold the button down for a slow count of 6 to 10 seconds (10 seconds is a common recommendation). This ensures the medication is fully delivered and prevents it from leaking out of the injection site when you withdraw the needle.

If no drop appears after 2-3 attempts, the needle may be clogged or bent. Attach a brand new needle and repeat the priming steps.

If a drop still doesn't appear, the cartridge may not be properly prepped. You may need to use the refillpen button like shown in the video below.

A hard-to-push button usually indicates a clogged or bent needle.

Do not force it.

Remove the needle, attach a new one, prime the pen, and try the injection again. Forcing the pen can damage the internal mechanism.

No, you must remove the needle after every injection. Leaving the needle attached can lead to air or contaminants entering the cartridge, medication leaking out, and the delicate pen mechanism failing.

When flying, always keep your pen and supplies in your carry-on luggage. Checked luggage can be exposed to freezing temperatures in the cargo hold, which will ruin the medication.

No. Even if covered, the temperature inside a car can quickly exceed the safe 86 Degree F limit, potentially within minutes. Never store the pen or cartridges in a car.

A reusable (or durable) injection pen is a device designed for multiple uses. It holds replaceable cartridges containing the medication (e.g., insulin, GLP-1s) and uses disposable pen needles. The pen features a dialing mechanism to accurately set and deliver the required dose.

While the initial purchase of a reusable pen is higher, replacement cartridges are often more cost-effective per unit of medication than buying an entirely new disposable pen, leading to long-term savings.

No, Refillpens do not use batteries, it is strictly a mechanical device.

Pen needles are strictly for single use. Reusing a needle dulls the tip, increases pain, and can lead to a blocked needle, infection, or damage the pen's internal mechanism.

This is usually caused by removing the pen too quickly. After pressing the injection button, hold the needle in the skin for a full 6-10 seconds to ensure the entire dose is absorbed and to stabilize the pressure.

The cost of a replacement cartridge is $1 per cartridge, and free shipping on orders over $49.

Reusable injection pens are often considered less painful than traditional syringes primarily because they use finer, shorter needles designed to minimize pain, deliver medication in a controlled and consistent manner, and are easier to handle, which helps reduce discomfort during injection. Additionally, many users experience less anxiety with pens, which can psychologically reduce the perception of pain.

Yes, Refillpen is your best option to purchase easy to use injectable pens. With various colors and types, as well as accessories and great support.

Refillpen.com is the best place to purchase colorful refillable pens online. And we continue to get new colors and offerings so keep checking to see if a new color is available!

Refillpen.com offers a wide variety of storage boxes. Ranging from holding 6, 15, and even 30, for all of your vial storage needs.